Study Shows no Evidence of a Mortality Benefit to PSA Screening

Source: JCNI: Journal of the National Cancer Institute

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Date of publication: January 2012

Publication type: Journal article

In a nutshell: The study shows men enrolled in the Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) Screening Trial had no evidence of a mortality benefit compared to a control group of men undergoing usual care.

Length of publication: Unknown

Some important notes: Please contact your local NHS Library for the full text of the article. Follow this link to find your local NHS Library.

Combination treatment halves deaths from locally advanced prostate cancer

Source: Cancer Research UK

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Date of publication: March 2011

Publication type: News item

In a nutshell: A new study suggests that a treatment approach combining radiotherapy with six months of prior hormone therapy could halve the risk of death from locally advanced prostate cancer – disease that has spread to the nearby tissue or organs.

Length of publication: Webpage

Prostate cancer urine test ‘twice as good’

Source: Nursing Times

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Date of publication: March 2011

Publication type: News item

In a nutshell: Scientists in the UK have developed a new prostate cancer urine test that could increase early diagnosis rates. The test looks for a protein secreted into the urine by prostate tumours. The test is claimed to be twice as good as the current PSA (prostate specific antigen) blood test.

Length of publication: Web page

‘One-off’ prostate cancer tests backed for 60-year-olds

Source: BBC News Health

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Date of publication: September, 2010

Publication type: News Item

In a nutshell: A study published in the British Medical Journal claims that a single blood test for all 60-year-old men could pick out the vast majority of those likely to die from prostate cancer. The blood test could reveal men who need no further checks and prevent many men from having unnecessary treatment following regular screening.

Length of publication: 1 webpage

Some important notes: The original articles was published in the BMJ.  This article is available in full text to all NHS Staff using Athens, for more information about accessing full text follow this link to find your local NHS Library.

Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments

Source: British Journal of Cancer, 2010, 103 p. 701-707

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Date of publication: August, 2010

Publication type: Journal Article

In a nutshell: Urinary Mcm5 detection seems to be a simple, accurate and noninvasive method for identifying patients with prostate cancer. Large-scale prospective trials are now required to evaluate this test in diagnosis and screening.

Length of publication: 6 pages

Some important notes: If item is a journal article in this section include “Please contact your local NHS Library for the full text of the article. Follow this link to find your local NHS Library. http://www.hlisd.org/

Study suggests screening in men with genetic predisposition to prostate cancer is more effective

Source: Cancer Research UK

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Date of publication: September, 2010

Publication type: News Item

In a nutshell: A new multinational study suggests that regular blood testing to measure levels of prostate specific antigen (PSA) is more effective at detecting prostate cancer in men with a genetic predisposition to the disease. Use of the PSA test as a screening tool for prostate cancer is controversial because many men with high levels do not have prostate cancer.

Length of publication: 1 web page

US doctors urge a more cautious approach to screening for prostate cancer

Source: British Medical Journal, 2010, 340:c1293

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Date of publication: March, 2010

Publication type: Journal article

In a nutshell: The American Cancer Society is urging a more cautious approach to screening for prostate cancer and asking men to make an informed decision about whether to have their level of prostate specific antigen measured. The revised guidelines, released on 3 March, are part of a periodic review of all guidelines.

Length of publication: 1 web page

Some important notes:Please contact your local NHS Library for the full text of the article. Follow this link to find your local NHS Library.  http://www.hlisd.org/

What now on screening for prostate cancer?

Source: Journal of Medical Screening, 2009, 16 (3) p. 109-111

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Date of publication: October 2009

Publication type: Journal Article

In a nutshell:  This article discusses a number of clinical trials and states that “…screening probably reduces prostate cancer mortality after about seven years or so, but this is not certain. More data are needed …despite the seemingly long follow-up in these trials the results were published prematurely.

Length of publication: 3 pages

 

Sound waves treat prostate cancer with fewer side effects

Source: Cancer Research UK 

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Date of publication: July, 2009

Publication type: News item

In a nutshell:An Experimental cancer therapy for prostate cancer may be able to treat men without surgery and offer fewer side effects according to the results of a UK study published in the British Journal of Cancer.

Length of publication: web page

Some important notes: The news item made reference to the original journal article from the British Journal of Cancer.

Prostate screening may have benefits

Source:Cancer Research UK, 2009

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Date of publication:April 2009

Publication type:News item

In a nutshell:CANCER RESEARCH UK scientists have shown that screening for prostate cancer using prostate specific antigen (PSA) would lead to a substantial number of tumours diagnosed at an earlier and more treatable stage. However, there would be likely cases of overdiagnosed prostate cancer according to a study published in the British Journal of Cancer today.

Length of publication:1 page news bulletin

Mortality results from a randomized prostate-cancer screening trial

Source: The New England Journal of Medicine

For fulltext link here

Year of publication: 2009

Publication type: Journal article

In a nutshell:  Investigators in the USA analyzed the effect of screening with prostate-specific–antigen (PSA) testing and digital rectal examination, as compared with usual care, on the rate of death from prostate cancer

Screening and prostate-cancer mortality in a randomized European study

Source: The New England Journal of Medicine

For fulltext link here

Year of publication: 2009

Publication type: Journal article

In a nutshell: In this trial, investigators tested the effect of prostate-specific–antigen testing on the death rate from prostate cancer. A significant reduction in prostate-cancer mortality was found after a median follow-up of 9 years .